Depolarization of the motor end-plate by decamethonium and acetylcholine
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چکیده
منابع مشابه
Effects of hexamethonium and decamethonium on end-plate current parameters.
The effects of neuromuscular blocking concentrations of hexamethomum and decamethonium on end-plate current parameters have been studied in frog sartorius nervemuscle preparations. In the presence of either drug, hyperpolarization of the cell membrane reduces the peak amplitude of the end-plate current despite the increase in driving force. The effect is larger for hexamethonium than for decame...
متن کاملSubstructure of Amphibian Motor End Plate
End-plate membrane has been examined at amphibian myoneural junctions by means of transmission electron microscopy of thin tissue sections. The postjunctional membrane exhibits morphologically specialized dense, convex patches which are located superficially facing the axon terminal but do not extend into the depths of the junctional folds. In the specialized regions the plasma membrane is appr...
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and 'Immunological associations of acquired neuromyotonia (Isaacs' syndrome). Report of five cases and literature review'. John Newsom-Davis published 12 original articles in Brain. Many dealt with autoimmunity in disorders of the neuromuscular junction or peripheral nerve. Together this work provided a foundation for knowledge on disorders resulting from autoantibodies directed at the acetylch...
متن کاملEnd-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease.
The synapse is a localized neurohumoral contact between a neuron and an effector cell and may be considered the quantum of fast intercellular communication. Analogously, the postsynaptic neurotransmitter receptor may be considered the quantum of fast chemical to electrical transduction. Our understanding of postsynaptic receptors began to develop about a hundred years ago with the demonstration...
متن کاملActivation of ion channels in the frog end-plate by high concentrations of acetylcholine.
1. The equilibrium relationship between acetylcholine (ACh) concentration and response (fraction of channels open), corrected for the effects of desensitization, has been estimated by single-ion-channel recording at the adult frog skeletal neuromuscular junction. At high ACh concentration channel openings occur in well-defined clusters separated by long desensitized intervals. The response, po,...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1951
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1951.sp004652